Relation of lifetime trauma and depressive symptoms to mortality in HIV
Identifieur interne : 002120 ( Main/Exploration ); précédent : 002119; suivant : 002121Relation of lifetime trauma and depressive symptoms to mortality in HIV
Auteurs : Jane Leserman [États-Unis] ; Brian Wells Pence ; Kathryn Whetten ; Michael J. Mugavero ; Nathan M. Thielman ; Marvin S. Swartz ; Dalene StanglSource :
- The American journal of psychiatry [ 0002-953X ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Traumatisme, Mortalité.
English descriptors
- KwdEn :
Abstract
Objective: In an era of highly active anti-retroviral therapies, the authors needed to confirm previous findings showing that stress and depression have an impact on HIV disease progression. The goal of the current study was to examine the effects of lifetime trauma, recent stressful events, and depression on all-cause and AIDS-related mortality among HIV-infected men and women. The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality. Method: The authors consecutively sampled HIV-infected men and women who received care at one of eight infectious diseases clinics in five Southeastern states. The sample included 490 patients who were followed by interview for 27 months and followed with their medical records for up to 41 months. Results: There were 29 deaths; 16 were AIDS-related. More lifetime trauma and antigenic marker on helper/inducer T cells (CD4) <200 significantly predicted faster all-cause and AIDS-related mortality. For those at or above the median in trauma, the all-cause death rate was 3.54 per 100 person-years, compared to 1.72 for those below the median. For those at or above the median in trauma, the AIDS-related death rate was 2.13 per 100 person-years, compared to 0.77 for those below the median. Depressive symptoms and higher baseline viral load were significantly related to greater risk of AIDS-related mortality. Conclusions: Further research is needed to determine if interventions to address trauma and depression can modify these detrimental effects on HIV.
Affiliations:
- États-Unis
- Angleterre, Caroline du Nord, Midlands de l'Ouest
- Birmingham, Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
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Le document en format XML
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Swartz</name></author><author><name sortKey="Stangl, Dalene" sort="Stangl, Dalene" uniqKey="Stangl D" first="Dalene" last="Stangl">Dalene Stangl</name></author></analytic><series><title level="j" type="main">The American journal of psychiatry</title><title level="j" type="abbreviated">Am. j. psychiatr.</title><idno type="ISSN">0002-953X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The American journal of psychiatry</title><title level="j" type="abbreviated">Am. j. psychiatr.</title><idno type="ISSN">0002-953X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Depression</term><term>Human immunodeficiency virus</term><term>Lifetime</term><term>Mortality</term><term>Symptomatology</term><term>Trauma</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Durée vie</term><term>Traumatisme</term><term>Symptomatologie</term><term>Etat dépressif</term><term>Mortalité</term><term>SIDA</term><term>Virus immunodéficience humaine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Traumatisme</term><term>Mortalité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: In an era of highly active anti-retroviral therapies, the authors needed to confirm previous findings showing that stress and depression have an impact on HIV disease progression. The goal of the current study was to examine the effects of lifetime trauma, recent stressful events, and depression on all-cause and AIDS-related mortality among HIV-infected men and women. The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality. Method: The authors consecutively sampled HIV-infected men and women who received care at one of eight infectious diseases clinics in five Southeastern states. The sample included 490 patients who were followed by interview for 27 months and followed with their medical records for up to 41 months. Results: There were 29 deaths; 16 were AIDS-related. More lifetime trauma and antigenic marker on helper/inducer T cells (CD4) <200 significantly predicted faster all-cause and AIDS-related mortality. For those at or above the median in trauma, the all-cause death rate was 3.54 per 100 person-years, compared to 1.72 for those below the median. For those at or above the median in trauma, the AIDS-related death rate was 2.13 per 100 person-years, compared to 0.77 for those below the median. Depressive symptoms and higher baseline viral load were significantly related to greater risk of AIDS-related mortality. Conclusions: Further research is needed to determine if interventions to address trauma and depression can modify these detrimental effects on HIV.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Angleterre</li><li>Caroline du Nord</li><li>Midlands de l'Ouest</li></region><settlement><li>Birmingham</li><li>Chapel Hill (Caroline du Nord)</li></settlement><orgName><li>Université de Caroline du Nord à Chapel Hill</li></orgName></list><tree><noCountry><name sortKey="Mugavero, Michael J" sort="Mugavero, Michael J" uniqKey="Mugavero M" first="Michael J." last="Mugavero">Michael J. Mugavero</name><name sortKey="Stangl, Dalene" sort="Stangl, Dalene" uniqKey="Stangl D" first="Dalene" last="Stangl">Dalene Stangl</name><name sortKey="Swartz, Marvin S" sort="Swartz, Marvin S" uniqKey="Swartz M" first="Marvin S." last="Swartz">Marvin S. Swartz</name><name sortKey="Thielman, Nathan M" sort="Thielman, Nathan M" uniqKey="Thielman N" first="Nathan M." last="Thielman">Nathan M. Thielman</name><name sortKey="Wells Pence, Brian" sort="Wells Pence, Brian" uniqKey="Wells Pence B" first="Brian" last="Wells Pence">Brian Wells Pence</name><name sortKey="Whetten, Kathryn" sort="Whetten, Kathryn" uniqKey="Whetten K" first="Kathryn" last="Whetten">Kathryn Whetten</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Leserman, Jane" sort="Leserman, Jane" uniqKey="Leserman J" first="Jane" last="Leserman">Jane Leserman</name></region><name sortKey="Leserman, Jane" sort="Leserman, Jane" uniqKey="Leserman J" first="Jane" last="Leserman">Jane Leserman</name><name sortKey="Leserman, Jane" sort="Leserman, Jane" uniqKey="Leserman J" first="Jane" last="Leserman">Jane Leserman</name><name sortKey="Leserman, Jane" sort="Leserman, Jane" uniqKey="Leserman J" first="Jane" last="Leserman">Jane Leserman</name><name sortKey="Leserman, Jane" sort="Leserman, Jane" uniqKey="Leserman J" first="Jane" last="Leserman">Jane Leserman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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